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Welcome to the Tang Group!

    Our research resides in the interdisciplinary area of organic synthesis, organometallic chemistry, medicinal chemistry, and process chemistry with particular emphasis on development of practical catalytic methodologies toward efficient syntheses of chiral natural products and drugs. We are keen to develop new reagents, ligands, and catalysts; design new synthetic routes to complex natural products; and provide scalable and green processes for active pharmaceutical ingredients. Students and researchers in our lab will learn frontiers in organic chemistry both academically and industrially, gain extensive synthetic experience, master air-free operation skills, and improve problem-solving abilities. Prospect students and postdoctoral fellows with real passion in science are welcome to join.
Recent Feature Publications:

29. "Rhodium-Catalyzed Asymmetric Reductive Hydroformylation of α-Substituted Enamides"
J. Am. Chem. Soc. 2024, just accepted.  [doi]

28. "Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation"
J. Am. Chem. Soc. 2024, 146, 27736-27744.  [doi]

27. "Dienediamine: A Safe Herbicide as Paraquat Surrogate"
Mol. Plant. 2023, 16, 1962-1975.  [doi]

26. "Total Syntheses of Polyhydroxylated Steroids by an Unsaturation-Functionalization Strategy"
Angew. Chem., Int. Ed. 2023, 62, e202303639.  [doi]

25. "Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons"
Angew. Chem., Int. Ed. 2023, 62, e202300334. (highlighted as Angew. Chem., Int. Ed. Hot Paper) [doi]

24. "Heck Reaction of N-Heteroaryl Halides for Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles"
Angew. Chem., Int. Ed. 2022, 61, e202209087. [doi]

23. "Enantioselective Construction of ortho-Sulfur- or Nitrogen-Substituted Axially Chiral Biaryls and Asymmetric Synthesis of Isoplagiochin D"
Nat. Commun. 2022, 13, 4577. [doi]

22. "Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β'‐Diketones"
Angew. Chem., Int. Ed. 2021, 60, 9978-9983. [doi]

21. "Asymmetric Hydroesterification of Diarylmethyl Carbinols"
Angew. Chem., Int. Ed. 2021, 60, 6305-6309. [doi]

20. "Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron"
J. Am. Chem. Soc.  2020, 142, 10337-10342. [doi]

19. "Enantioselective Cross-Coupling for Axially Chiral Tetra-ortho-Substituted Biaryls and Asymmetric Synthesis of Gossypol"
J. Am. Chem. Soc. 2020, 142, 8036–8043. [doi]

18. "Expedite Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization"
Angew. Chem., Int. Ed. 2020, 59, 8143-8147. [doi]

17. "Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamine"
Angew. Chem., Int. Ed. 2019, 58, 16119-16123.(highlighted as Angew. Chem., Int. Ed. VIP Paper) [doi]

16. "Stereoelectronic Effects in Ligand Design: Enantioselective RhodiumCatalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib"
Angew. Chem., Int. Ed.  2019, 58, 13573-13583.  [doi]

15. "P‑Chiral Phosphorus Ligands Based on a 2,3-Dihydrobenzo[d][1,3]oxaphosphole Motif for Asymmetric Catalysis"
Acc. Chem. Res. 2019, 52, 1101 –1112. [doi]

14. "Enantioselective Palladium-Catalyzed Cross-Coupling between α-Bromo Carboxamides and Arylboronic Acids"
Angew. Chem., Int. Ed.  2019, 58, 11355-11359.   [doi]

13. "Efficient Synthesis of (‐)‐Corynoline by Sterically Hindered Enantioselective Palladium‐Catalyzed α‐Arylation"
Angew. Chem., Int. Ed. 2018, 57, 12328 –12332. [doi]

12. "Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles: A Crucial CONH Effect"
Angew. Chem., Int. Ed. 2018, 57, 7176-7180.[doi]

11. "Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons"
J. Am. Chem. Soc. 2017, 139, 9767-9770. [doi]

10. "Efficient Enantioselective Syntheses of (+)-Dalesconol A and B"
J. Am. Chem. Soc. 2017, 139, 3360-3363. [doi]

9. "Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles"
J. Am. Chem. Soc. 2016, 138, 10774-10777. [doi]

8. "Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation Reactions"
Angew. Chem., Int. Ed. 2016, 55, 5044–5048. [doi]
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7. "Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram"
Angew. Chem., Int. Ed. 2016, 55, 4527–4531. [doi]

6. "Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective hydroboration of α-Arylenamides"
J. Am. Chem. Soc. 2015, 137, 6746-6749. [doi]

5. "Enantioselective Palladium-Catalyzed Dearomative Cyclization for Efficient Synthesis of Terpenes and Steroids"
Angew. Chem., Int. Ed. 2015, 54, 3033-3037. (hot paper, highlighted by Synfacts).[doi]

4. "Efficient Syntheses of Sterically Hindered Acyclic Secondary Alkyl Arenes by Suzuki-Miyaura Cross-Couplings"
Angew. Chem., Int. Ed. 2015, 54, 3792-3796. [doi]

3. "Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynones"
Angew. Chem., Int. Ed. 2015, 54, 2520-2524. (highlighted by Synfacts) [doi]

2. "Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions"
J. Am. Chem. Soc. 2014, 136, 570-573. (highlighted as JACS Cover Paper, by Synfacts) [doi]

1. "Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis fo Chiral β-Arylamines by Asymmetric Hydrogenation"
Angew. Chem., Int. Ed. 2013, 52, 4235-4238. (Highlighted in Chin. J. Org. Chem.; Chemistry Portal Highlights) [doi]


 


This page was last updated on August 12, 2018