Welcome to the Tang Group!

    Our research resides in the interdisciplinary area of organic synthesis, organometallic chemistry, medicinal chemistry, and process chemistry with particular emphasis on development of practical catalytic methodologies toward efficient syntheses of chiral natural products and drugs. We are keen to develop new reagents, ligands, and catalysts; design new synthetic routes to complex natural products; and provide scalable and green processes for active pharmaceutical ingredients. Students and researchers in our lab will learn frontiers in organic chemistry both academically and industrially, gain extensive synthetic experience, master air-free operation skills, and improve problem-solving abilities. Prospect students and postdoctoral fellows with real passion in science are welcome to join.

Recent Feature Publications:

1. "Pyrrolidines and piperidines bearing chiral tertiary alcohols by nickel-catalyzed enantioselective reductive cyclization of N-alkynones"
Communications Chemistry 2018 [doi]

2. "Ligand-free nickel-catalyzed Kumada couplings of aryl bromides with tert-butyl Grignard reagents"
Chinese Chemical Letters 2018, 30, 597-600. [doi]

3. "Optically active N-alkyl aziridines via stereospecific reductive cyclization of α-mesylated acetamides"
Org. Chem. Front., 2018, 5, 2723-2727. [doi]

4. "Efficient Synthesis of (‐)‐Corynoline by Sterically Hindered Enantioselective Palladium‐Catalyzed α‐Arylation"
Angew. Chem., Int. Ed. 2018 [doi]

5. "Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles: A Crucial CONH Effect"
Angew. Chem., Int. Ed. 2018, 57, 7176-7180.[doi]

6. "Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons"
J. Am. Chem. Soc. 2017, 139, 9767-9770. [doi]

7. "Efficient Enantioselective Syntheses of (+)-Dalesconol A and B"
J. Am. Chem. Soc. 2017, 139, 3360-3363. [doi]

8. "Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles"
J. Am. Chem. Soc. 2016, 138, 10774-10777. [doi]

9. "Transition-metal catalyzed asymmetric carbon–carbon cross-coupling with chiral ligands"
Tetrahedron 2016, 72, 6143-6174. [doi]

10. “Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation Reactions”
Angew. Chem., Int. Ed. 2016, 55, 5044–5048. [doi]
11. “Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Aryl Ketones: Efficient Synthesis of Escitalopram”
Angew. Chem., Int. Ed. 2016, 55, 4527–4531. [doi]

12. "Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective hydroboration of α-Arylenamides"
J. Am. Chem. Soc. 2015, 137, 6746-6749. [doi]

13. "Enantioselective Palladium-Catalyzed Dearomative Cyclization for Efficient Synthesis of Terpenes and Steroids"
Angew. Chem., Int. Ed. 2015, 54, 3033-3037. (hot paper, highlighted by Synfacts).[doi]

14. "Efficient Syntheses of Sterically Hindered Acyclic Secondary Alkyl Arenes by Suzuki-Miyaura Cross-Couplings"
Angew. Chem., Int. Ed. 2015, 54, 3792-3796. [doi]

15. "Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynones"
Angew. Chem., Int. Ed. 2015, 54, 2520-2524. (highlighted by Synfacts) [doi]

16. "Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions"
J. Am. Chem. Soc. 2014, 136, 570-573. (highlighted as JACS Cover Paper, by Synfacts) [doi]

17. "Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis fo Chiral β-Arylamines by Asymmetric Hydrogenation"
Angew. Chem., Int. Ed. 2013, 52, 4235-4238. (Highlighted in Chin. J. Org. Chem.; Chemistry Portal Highlights) [doi]


This page was last updated on August 12, 2018